Sixty-one years old male was admitted in the In-patient Department of Siddha Hospital with complaints of Diabetic foot ulcer (DFU) in the left plantar aspect of foot with foul odor, pus discharge from the ulcer, swelling in the peri-wound area, Pain, altered gait along with a mild gangrene with osteomyelitis for the past 12-months associated with history of Diabetes mellitus for the past 20 years. The Severity of the ulcer was measured by the Diabetic Ulcer Severity Score (DUSS), Classification of Ulcer by the ‘Wagner Ulcer Classification System’ (WUCS), prognosis by ‘Leg Ulcer Measurement Tool’ (LUMT). And, it emphasizes on the importance of proper medication for DFU and to focus on the Siddha management with D5 Chooranam (Anti-diabetic Siddha drug) and Maththan Thailam (Wound healing Siddha external Oil) and Palagaraiparpam. Conclusion: Intervention of Siddha medicine can potentially heal the Diabetic foot ulcer with regulating the blood sugar level. They could have a massive impact, in reducing infection rates, amputations, plastic surgeries and improving the overall quality of life and lower the economic burden in treating DFU.